The role of biomarkers in early prediction and molecular mechanisms of preeclampsia

Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence maternal organ or uteroplacental dysfunction proteinuria. PE a leading cause death, about 55000 deaths worldwide each year. Toxic substances that damage the vascular endothelium induce PE, resulting in liver and kidney malfunction. It crucial for obstetricians to identify early possible patients who are at risk PE. Polycystic ovarian disease, sleeping disorders, urinary infections, periodontal smoking, lifestyle familial history major factors involved this disease. VEGF, sFlt1, sENG, PAPP-A, inhibin A activin proteins, fetal hemoglobin, heat shock protein placental have been helpful predicting diagnosing understanding its pathogenesis. In addition, better pathogenesis would aid identifying most effective treatments do not impair fetus’ prognosis. The aim our study review pathophysiology biomarkers, such pro- anti-angiogenic substances, may be useful detection future.